Methotrexate is a potent medication primarily used to treat certain types of cancer, autoimmune diseases, and ectopic pregnancies. It works by inhibiting the growth of rapidly dividing cells, making it effective for conditions where cell proliferation is a concern.

Methotrexate FAQ


What is Methotrexate used for?

Methotrexate is commonly used to treat cancers, rheumatoid arthritis, and psoriasis.

How does Methotrexate work?

It interferes with the metabolism of cells, particularly those that divide rapidly.

What are the side effects of Methotrexate?

Possible side effects include nausea, fatigue, and hair loss, among others.

How should I take Methotrexate?

Follow your doctor’s instructions, as methotrexate can be taken orally or via injection.

Can Methotrexate cause long-term effects?

Yes, long-term use may lead to liver damage and other complications.

Is Methotrexate safe during pregnancy?

No, Methotrexate is generally contraindicated in pregnancy due to risks to the fetus.

Can Methotrexate be used for Crohn's disease?

Yes, it is sometimes prescribed for Crohn's disease and other inflammatory conditions.

How often do I need to take Methotrexate?

Dosing varies by condition; your healthcare provider will determine the best schedule.

What should I avoid while taking Methotrexate?

Avoid alcohol and consult your doctor about any other medications.

How can I manage Methotrexate side effects?

Regular blood tests and good communication with your doctor can help manage side effects.

Can I stop taking Methotrexate suddenly?

Do not stop taking it without consulting your healthcare provider.

How long does Methotrexate take to work?

It may take several weeks to notice improvements, depending on your condition.

What are the signs of Methotrexate toxicity?

Signs include mouth sores, unusual bruising, and severe fatigue. Seek medical attention if these occur.

Can I take Methotrexate with other medications?

Some medications may interact with Methotrexate. Discuss with your doctor first.

Is regular monitoring necessary while on Methotrexate?

Yes, regular blood tests are important to monitor liver function and blood cell counts.

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Information provided by Dr. Tekeste Etay Teka. Reviewed by Dr. Mohamed El Khouly